Inspired by the real Dante Alighieri, but adapted for a new generation and a new medium, the hero of the game is a soldier who defies death and fights for love against impossible odds. The Italian mercenary Dante returns home from the wars to find that his beloved Beatrice has been murdered, and her soul pulled down into Hell by a dark force. He gives chase, and vows to get her back. For weapons, he wields Death's soul-reaping scythe, and commands holy powers of the cross, given to him by Beatrice.

"At the midpoint on the journey of life, I found myself in a dark forest, for the clear path was lost" (opening line of The Divine Comedy). In the game, Dante goes on a spectacular journey through the afterlife to save his beloved Beatrice from the clutches of evil. But what starts out as a rescue mission quickly changes into a redemption story, where Dante must confront his own dark past and the sins he carries with him into Hell. He faces the epic inhospitable terrain of the underworld, huge monsters and guardians, sinister demons, the people and sins of his past, and the ultimate traitor: Lucifer himself.